Peptide-Chitosan Composites as New Biomaterials for Diabetic Wound Care with Peptide Power and Hydrogel Magic!
Nazwa projektu:
Peptide-Chitosan Composites as New Biomaterials for Diabetic Wound Care with Peptide Power and Hydrogel Magic!
Numer umowy:
SPPW/CHITOCARE/0074/2024
Akronim projektu:
CHITOCARE
Opis projektu:
The global market for diabetic wound dressings is rapidly growing due to the increasing prevalence of diabetes and related complications. In 2023, it was valued at USD 11.09 billion and is expected to grow at a CAGR of 7.36%, reaching USD 18.25 billion by 2030 (Fortune Business Insights). Approximately 15% of individuals with diabetes develop chronic wounds. The main issue is poor blood circulation, leading to tissue death and delayed healing due to low nutrients and oxygen supply. Therefore, the key goal of CHITOCARE is the development of advanced wound dressings that enhance the vascularization, stem cell homing while reducing inflammation. To achieve these goals, bioactive pro-angiogenic, stem cell-homing and anti-inflammatory peptides will be incorporated into novel chitosan-based scaffolds (PCH). This PCH will be cross-linked using a patented, eco-friendly technology, resulting in two distinct forms: a hydrogel dressing and spray that will undergo comprehensive physicochemical characterization and rigorous testing in vitro and in vivo. Initial efforts will focus on the design and synthesis of peptides to promote angiogenesis and regeneration, and trigger M2-macrophage polarization. Moreover, sterilisation and packaging techniques for the final product will be developed with the aim of achieving reproducible production and GMP-compliant registration by the end of the project. The project outcomes will include affordable, effective and easy-to be used hydrogel and spray dressings tailored for the treatment of diabetic wounds. The core of CHITOCARE's methodology combines chemical synthesis, cell culture and animal testing with state-of-the-art dressing technology to evaluate the biological activity of novel peptides and proteins in stimulating angiogenesis. The CHITOCARE, spearheads the innovation in diabetic wound management through an interdisciplinary consortium of leading researchers in medicinal chemistry, chemical engineering, cell and regenerative biology.
Koszt projektu:
4 482 169.75 PLN
Dofinansowanie NCBiR:
4 391 989.75 PLN
Peptide-Chitosan Composites as New Biomaterials for Diabetic Wound Care with Peptide Power and Hydrogel Magic!
Nazwa projektu:
Peptide-Chitosan Composites as New Biomaterials for Diabetic Wound Care with Peptide Power and Hydrogel Magic!
Numer umowy:
SPPW/CHITOCARE/0074/2024
Akronim projektu:
CHITOCARE
Opis projektu:
The global market for diabetic wound dressings is rapidly growing due to the increasing prevalence of diabetes and related complications. In 2023, it was valued at USD 11.09 billion and is expected to grow at a CAGR of 7.36%, reaching USD 18.25 billion by 2030 (Fortune Business Insights). Approximately 15% of individuals with diabetes develop chronic wounds. The main issue is poor blood circulation, leading to tissue death and delayed healing due to low nutrients and oxygen supply. Therefore, the key goal of CHITOCARE is the development of advanced wound dressings that enhance the vascularization, stem cell homing while reducing inflammation. To achieve these goals, bioactive pro-angiogenic, stem cell-homing and anti-inflammatory peptides will be incorporated into novel chitosan-based scaffolds (PCH). This PCH will be cross-linked using a patented, eco-friendly technology, resulting in two distinct forms: a hydrogel dressing and spray that will undergo comprehensive physicochemical characterization and rigorous testing in vitro and in vivo. Initial efforts will focus on the design and synthesis of peptides to promote angiogenesis and regeneration, and trigger M2-macrophage polarization. Moreover, sterilisation and packaging techniques for the final product will be developed with the aim of achieving reproducible production and GMP-compliant registration by the end of the project. The project outcomes will include affordable, effective and easy-to be used hydrogel and spray dressings tailored for the treatment of diabetic wounds. The core of CHITOCARE's methodology combines chemical synthesis, cell culture and animal testing with state-of-the-art dressing technology to evaluate the biological activity of novel peptides and proteins in stimulating angiogenesis. The CHITOCARE, spearheads the innovation in diabetic wound management through an interdisciplinary consortium of leading researchers in medicinal chemistry, chemical engineering, cell and regenerative biology.
Koszt projektu:
4 482 169.75 PLN
Dofinansowanie NCBiR:
4 391 989.75 PLN
